To solve this problem, we need to identify which disease is caused by an autosomal primary non-disjunction. Let's analyze each option:$\newline \bullet$Klinefelter’s syndrome:$\newline$ - Klinefelter’s syndrome is a genetic condition that affects males, caused by the presence of an extra X chromosome (XXY).$\newline$ - It is a result of non-disjunction of sex chromosomes, not autosomes.$\newline \bullet$Turner’s syndrome:$\newline$ - Turner’s syndrome is a condition affecting females, where one of the X chromosomes is missing or partially missing (XO).$\newline$ - This is also due to non-disjunction of sex chromosomes.$\newline \bullet$Sickle cell anemia:$\newline$ - Sickle cell anemia is a genetic disorder caused by a mutation in the hemoglobin-beta gene found on chromosome 11.$\newline$ - It is not caused by non-disjunction but by a point mutation.$\newline \bullet$Down’s syndrome:$\newline$ - Down’s syndrome, also known as Trisomy 21, is caused by an extra copy of chromosome 21.$\newline$ - This is a result of autosomal primary non-disjunction.$\newline$Therefore, the disease caused by an autosomal primary non-disjunction is Down’s syndrome.$\newline$This corresponds to Option 4.