To solve this problem, we need to understand the components of an enzyme. Let's analyze each option:$\newline \bullet$Option 1: Holoenzyme = Apoenzyme + Coenzyme$\newline$ - A holoenzyme is the active form of an enzyme, which includes both the protein part (apoenzyme) and the non-protein part (coenzyme or cofactor).$\newline$ - This statement is correct.$\newline \bullet$Option 2: Coenzyme = Apoenzyme + Holoenzyme$\newline$ - A coenzyme is a non-protein molecule that binds with an apoenzyme to form a holoenzyme.$\newline$ - This statement is incorrect because a coenzyme is not formed by combining an apoenzyme and a holoenzyme.$\newline \bullet$Option 3: Holoenzyme = Coenzyme + Co-factor$\newline$ - A holoenzyme is formed by an apoenzyme and a coenzyme or cofactor, not by combining a coenzyme and a cofactor.$\newline$ - This statement is incorrect.$\newline \bullet$Option 4: Apoenzyme = Holoenzyme + Coenzyme$\newline$ - An apoenzyme is the protein part of an enzyme, which becomes active only when combined with a coenzyme or cofactor to form a holoenzyme.$\newline$ - This statement is incorrect.$\newline$Therefore, the correct statement is Option 1: Holoenzyme = Apoenzyme + Coenzyme.