To solve this problem, we need to understand the role of the i gene in the lac operon of E. coli and the effect of its mutation.$\newline \bullet$The lac operon consists of three structural genes: z, y, and a, which code for $\beta$-galactosidase, permease, and transacetylase, respectively.$\newline \bullet$The i gene codes for the repressor protein, which can bind to the operator region to inhibit transcription of the operon.$\newline \bullet$In the presence of an inducer like lactose, the repressor binds to the inducer, causing a conformational change that prevents it from binding to the operator, allowing transcription.$\newline \bullet$In this scenario, the i gene is mutated such that its product (the repressor) cannot bind the inducer molecule.$\newline \bullet$As a result, the repressor will remain bound to the operator, even in the presence of lactose, preventing transcription of the z, y, and a genes.$\newline$Therefore, the z, y, a genes will not be translated, corresponding to Option 3.